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KMID : 0620920120440070432
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Experimental & Molecular Medicine
2012 Volume.44 No. 7 p.432 ~ p.439
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Platinum nanoparticles reduce ovariectomy-induced bone loss by decreasing osteoclastogenesis
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Kim Woon-Ki
Kim Jin-Chun
Park Hyun-Jung
Sul Ok-Joo
Lee Mi-Hyun
Kim Ji-Soon
Choi Hye-Seon
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Abstract
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Platinum nanoparticles (PtNP) exhibit remarkable antioxidant activity. There is growing evidence concerning a positive relationship between oxidative stress and bone loss, suggesting that PtNP could protect against bone loss by modulating oxidative stress. Intragastric administration of PtNP reduced ovariectomy (OVX)-induced bone loss with a decreased level of activity and number of osteoclast (OC) in vivo. PtNP inhibited OC formation by impairing the receptor activator of nuclear factor-κB ligand (RANKL) signaling. This impairment was due to a decreased activation of nuclear factor-κB and a reduced level of nuclear factor in activated T-cells, cytoplasmic 1 (NFAT2). PtNP lowered RANKL-induced long lasting reactive oxygen species as well as intracellular concentrations of Ca2+ oscillation. Our data clearly highlight the potential of PtNP for the amelioration of bone loss after estrogen deficiency by attenuated OC formation.
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KEYWORD
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NFAT2, osteoclasts, osteoporosis, ovariectomy, platinum nanoparticles, RANK ligand
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